2CD-2,5-DiEtO

2CD-2,5-DiEtO
Clinical data
Other names2CD-DiEtO; 2CD-Di-EtO; 2CD-DIETO; 2CD-DI-ETO; 2,5-Diethoxy-4-methylphenethylamine; 4-Methyl-2,5-diethoxyphenethylamine
Routes of
administration		Oral[1][2][3]
Drug classPsychoactive drug
ATC code
  • None
Pharmacokinetic data
Duration of action4 hours[1][2][3]
Identifiers
  • 2-(2,5-diethoxy-4-methylphenyl)ethan-1-amine
Chemical and physical data
FormulaC13H21NO2
Molar mass223.316 g·mol−1
3D model (JSmol)
  • CCOC1=CC(CCN)=C(OCC)C=C1C
  • InChI=1S/C13H21NO2/c1-4-15-12-9-11(6-7-14)13(16-5-2)8-10(12)3/h8-9H,4-7,14H2,1-3H3
  • Key:ALVWRNQBQUMSMA-UHFFFAOYSA-N

2CD-2,5-DiEtO, also known as 2,5-diethoxy-4-methylphenethylamine, is a psychoactive drug of the phenethylamine, 2C, and TWEETIO families related to the psychedelic drug 2C-D.[1][2][3] It is the derivative of 2C-D in which the methoxy groups at the 2 and 5 positions have been replaced with ethoxy groups.[1][2][3]

According to Alexander Shulgin in his book PiHKAL (Phenethylamines I Have Known and Loved) and other publications, 2CD-2,5-DiEtO's dose is greater than 55 mg orally and its duration is 4 hours.[1][2][3] 2CD-2,5-DiEtO has been described as producing mild effects that were no greater than a "plus-one" on the Shulgin Rating Scale.[1][2][3] No specific effects have been described and higher doses were not tested.[1][2][3]

The chemical synthesis of 2CD-2,5-DiEtO has been described.[1]

2CD-2,5-DiEtO was first described in the literature by Shulgin in PiHKAL in 1991.[1] It was developed and tested by Darrell Lemaire, with publication via personal communication with Shulgin.[2][4][5][6][7] The drug is a controlled substance in Canada under phenethylamine blanket-ban language.[8]

See also

References

  1. 1 2 3 4 5 6 7 8 9 Shulgin A, Shulgin A (September 1991). PiHKAL: A Chemical Love Story. Berkeley, California: Transform Press. ISBN 0-9630096-0-5. OCLC 25627628. "The 2,5-di-EtO homologue of 2C-D is 2,5-diethoxy-4-methylphenethylamine, or 2CD-2,5-DIETO. The benzaldehyde (2,5-diethoxy-4-tolualdehyde) had a melting point of 102–103 °C, the nitrostyrene intermediate a melting point of 108–109 °C, and the final hydrochloride salt a melting point of 251–252 °C. At a level of 55 milligrams, a plus one was reached, and what effects there were, were gone after four hours."
  2. 1 2 3 4 5 6 7 8 Shulgin AT (2003). "Basic Pharmacology and Effects". In Laing RR (ed.). Hallucinogens: A Forensic Drug Handbook. Forensic Drug Handbook Series. Elsevier Science. pp. 67–137. ISBN 978-0-12-433951-4. Archived from the original on 13 July 2025.
  3. 1 2 3 4 5 6 7 Trachsel D, Lehmann D, Enzensperger C (2013). Phenethylamine: von der Struktur zur Funktion [Phenethylamines: From Structure to Function]. Nachtschatten-Science (in German) (1 ed.). Solothurn: Nachtschatten-Verlag. ISBN 978-3-03788-700-4. OCLC 858805226. Archived from the original on 21 August 2025.
  4. ↑ "Erowid Darrell Lemaire Vault". erowid.org. Retrieved 14 November 2025.
  5. ↑ Morris H (7 December 2016). "The Lazy Lizard School of Hedonism". Hamilton's Pharmacopeia. Season 1. Episode 6. Vice Media. Viceland.
  6. ↑ Nez H, Lemaire D (2010). "Notes About Psychoactive Compounds" (PDF). In Targ R, Radin D (eds.). Radiant Minds: Scientists Explore the Dimensions of Consciousness. Millay. pp. 201–207. ISBN 978-0-615-29633-3.
  7. ↑ Nez H, Lemaire D (Lazar) (1990). Certain Exotic Transmitters as Smart Pills or Compounds that Increase the Capacity for Mental Work in Humans: A Story About LAZAR as Told by Hosteen Nez (2nd ed.). Archived from the original (PDF) on 9 July 2001.
  8. ↑ "Controlled Drugs and Substances Act". Department of Justice Canada. Retrieved 19 January 2026.
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