The 2005 Southern League was a Class AA baseball season played between April 7 and September 5. Ten teams played a 140-game schedule, with the top team in each division in each half of the season qualifying for the post-season.
The Jacksonville Suns won the Southern League championship, defeating the West Tenn Diamond Jaxx in the playoffs.
Teams
| 2005 Southern League |
| Division | Team | City | MLB Affiliate | Stadium |
| North |
Carolina Mudcats |
Zebulon, North Carolina |
Florida Marlins |
Five County Stadium |
| Chattanooga Lookouts |
Chattanooga, Tennessee |
Cincinnati Reds |
Bellsouth Park |
| Huntsville Stars |
Huntsville, Alabama |
Milwaukee Brewers |
Joe W. Davis Stadium |
| Tennessee Smokies |
Sevierville, Tennessee |
Arizona Diamondbacks |
Smokies Park |
| West Tenn Diamond Jaxx |
Jackson, Tennessee |
Chicago Cubs |
Pringles Park |
| South |
Birmingham Barons |
Birmingham, Alabama |
Chicago White Sox |
Hoover Metropolitan Stadium |
| Jacksonville Suns |
Jacksonville, Florida |
Los Angeles Dodgers |
Baseball Grounds of Jacksonville |
| Mississippi Braves |
Jackson, Mississippi |
Atlanta Braves |
Trustmark Park |
| Mobile BayBears |
Mobile, Alabama |
San Diego Padres |
Hank Aaron Stadium |
| Montgomery Biscuits |
Montgomery, Alabama |
Tampa Bay Devil Rays |
Montgomery Riverwalk Stadium |
Map of teams

North Division

South Division
League Leaders
Pitching leaders
[3]
| Stat |
Player |
Total |
| W | Ricky Nolasco, West Tenn Diamond Jaxx Sean Tracey, Birmingham Barons | 14 |
| ERA | Daniel Haigwood, Birmingham Barons | 1.74 |
| CG | Charlie Haeger, Birmingham Barons Jason Hammel, Montgomery Biscuits Dustin Nippert, Tennessee Smokies | 3 |
| SHO | Enrique González, Tennessee Smokies Charlie Haeger, Birmingham Barons Dustin Nippert, Tennessee Smokies | 2 |
| SV | Dale Thayer, Mobile BayBears | 27 |
| IP | Jae Kuk Ryu, West Tenn Diamond Jaxx | 169.2 |
| SO | Ricky Nolasco, West Tenn Diamond Jaxx | 173 |