The 1995 Southern League was a Class AA baseball season played between April 6 and September 4. Ten teams played a 144-game schedule, with the top team in each division in each half of the season qualifying for the post-season.
The Carolina Mudcats won the Southern League championship, as they defeated the Chattanooga Lookouts in the playoffs.
Teams
| 1995 Southern League |
| Division | Team | City | MLB Affiliate | Stadium |
| East |
Carolina Mudcats |
Zebulon, North Carolina |
Pittsburgh Pirates |
Five County Stadium |
| Greenville Braves |
Greenville, South Carolina |
Atlanta Braves |
Greenville Municipal Stadium |
| Jacksonville Suns |
Jacksonville, Florida |
Detroit Tigers |
Wolfson Park |
| Orlando Cubs |
Orlando, Florida |
Chicago Cubs |
Tinker Field |
| Port City Roosters |
Wilmington, North Carolina |
Seattle Mariners |
Brooks Field |
| West |
Birmingham Barons |
Birmingham, Alabama |
Chicago White Sox |
Hoover Metropolitan Stadium |
| Chattanooga Lookouts |
Chattanooga, Tennessee |
Cincinnati Reds |
Engel Stadium |
| Huntsville Stars |
Huntsville, Alabama |
Oakland Athletics |
Joe W. Davis Stadium |
| Knoxville Smokies |
Knoxville, Tennessee |
Toronto Blue Jays |
Bill Meyer Stadium |
| Memphis Chicks |
Memphis, Tennessee |
San Diego Padres |
Tim McCarver Stadium |
Map of teams

East Division

West Division
Regular season
Summary
- The Carolina Mudcats finished the season with the best record in the league for the first time in franchise history.
League Leaders
Pitching leaders
[3]
| Stat |
Player |
Total |
| W | Elmer Dessens, Carolina Mudcats | 15 |
| ERA | Elmer Dessens, Carolina Mudcats | 2.49 |
| CG | Rob Mattson, Memphis Chicks | 11 |
| SHO | Rob Mattson, Memphis Chicks Matt Ruebel, Carolina Mudcats Clint Sodowsky, Jacksonville Suns | 3 |
| SV | John Kelly, Jacksonville Suns Rusty Kilgo, Chattanooga Lookouts | 29 |
| IP | Rob Mattson, Memphis Chicks | 202.1 |
| SO | Osvaldo Fernández, Port City Roosters | 162 |