| 1985 regular season game log: 101–61 (Home: 54–27; Away: 47–34) |
April: 8–11 (Home: 7–3; Away: 1–8)
| # | Date | Time (CT) | Opponent | Score | Win | Loss | Save | Time of Game | Attendance | Record | Box/ Streak |
| 1 | April 9 | 12:35 p.m. CST | @ Mets | L 5–6 (10) | Gorman (1–0) | Allen (0–1) | – | 3:42 | 46,781 | 0–1 | L1 |
| 2 | April 11 | 12:35 p.m. CST | @ Mets | L 1–2 (11) | McDowell (1–0) | Hassler (0–1) | – | 3:26 | 18,864 | 0–2 | L2 |
| 3 | April 12 | 5:05 p.m. CST | @ Pirates | L 4–6 | Robinson (1–0) | Kepshire (0–1) | Candelaria (1) | 2:34 | 47,335 | 0–3 | L3 |
| 4 | April 13 | 6:05 p.m. CST | @ Pirates | L 3–4 | Candelaria (1–0) | Campbell (0–1) | – | 2:36 | 9,171 | 0–4 | L4 |
| 5 | April 14 | 12:35 p.m. CST | @ Pirates | W 10–4 | Andújar (1–0) | Rhoden (0–2) | – | 2:44 | 12,483 | 1–4 | W1 |
| 6 | April 15 | 7:35 p.m. CST | Expos | W 6–1 | Forsch (1–0) | Gullickson (1–1) | – | 2:09 | 42,986 | 2–4 | W2 |
| 7 | April 17 | 7:35 p.m. CST | Expos | L 1–2 | Hesketh (1–0) | Tudor (0–1) | Reardon (1) | 2:14 | 20,145 | 2–5 | L1 |
| 8 | April 18 | 12:35 p.m. CST | Expos | L 1–7 | Rogers (1–2) | Kepshire (0–2) | – | 2:31 | 19,953 | 2–6 | L2 |
| 9 | April 19 | 7:35 p.m. CST | Pirates | W 5–4 | Andújar (2–0) | Candelaria (1–2) | Allen (1) | 2:44 | 30,510 | 3–6 | W1 |
| 10 | April 20 | 7:05 p.m. CST | Pirates | W 4–3 | Cox (1–0) | Tunnell (0–1) | Allen (2) | 2:28 | 32,978 | 4–6 | W2 |
| 11 | April 21 | 1:15 p.m. CST | Pirates | W 6–0 | Forsch (2–0) | DeLeón (0–2) | – | 2:27 | 28,880 | 5–6 | W3 |
| 12 | April 22 | 7:35 p.m. CST | Mets | L 6–7 | Schiraldi (1–0) | Tudor (0–2) | Orosco (2) | 2:49 | 16,324 | 5–7 | L1 |
| 13 | April 23 | 7:35 p.m. CST | Mets | W 8–3 | Kepshire (1–2) | Gorman (1–1) | – | 2:49 | 13,028 | 6–7 | W1 |
| 14 | April 24 | 12:35 p.m. CST | Mets | W 5–1 | Andújar (3–0) | Gooden (2–1) | – | 2:16 | 29,282 | 7–7 | W2 |
| 15 | April 25 | 12:35 p.m. CST | @ Expos | L 2–4 | Gullickson (3–1) | Cox (1–1) | Reardon (4) | 2:23 | 10,203 | 7–8 | L1 |
| 16 | April 26 | 2:35 p.m. CST | @ Expos | L 5–10 | Palmer (1–2) | Forsch (2–1) | – | 3:04 | 10,264 | 7–9 | L2 |
| 17 | April 27 | 12:35 p.m. CST | @ Expos | L 3–8 | Hesketh (2–1) | Tudor (0–3) | Roberge (1) | 2:30 | 15,171 | 7–10 | L3 |
| 18 | April 28 | 12:35 p.m. CDT | @ Expos | L 3–5 | Rogers (2–2) | Kepshire (1–3) | Reardon (5) | 3:16 | 14,426 | 7–11 | L4 |
| 19 | April 30 | 7:35 p.m. CDT | Dodgers | W 6–1 | Andújar (4–0) | Reuss (1–3) | – | 2:40 | 20,380 | 8–11 | W1 |
|
May: 16–10 (Home: 7–3; Away: 9–7)
| # | Date | Time (CT) | Opponent | Score | Win | Loss | Save | Time of Game | Attendance | Record | Box/ Streak |
| 20 | May 1 | 12:35 p.m. CDT | Dodgers | L 1–2 (12) | Howell (1–1) | Allen (0–2) | Niedenfuer (1) | 3:40 | 14,324 | 8–12 | L1 |
| 21 | May 3 | 7:35 p.m. CDT | Giants | W 8–1 | Tudor (1–3) | Krukow (2–1) | – | 2:27 | 32,441 | 9–12 | W1 |
| 22 | May 4 | 7:05 p.m. CDT | Giants | W 6–4 | Kepshire (2–3) | Hammaker (0–3) | Lahti (1) | 2:27 | 41,410 | 10–12 | W2 |
| 23 | May 5 | 1:15 p.m. CDT | Giants | L 0–5 | LaPoint (1–4) | Andújar (4–1) | – | 2:22 | 31,322 | 10–13 | L1 |
| 24 | May 6 | 7:35 p.m. CDT | Padres | W 5–2 | Cox (2–1) | Show (2–1) | Lahti (2) | 2:41 | 28,260 | 11–13 | W1 |
| 25 | May 7 | 12:35 p.m. CDT | Padres | L 2–12 | Dravecky (1–2) | Forsch (2–2) | – | 2:26 | 18,682 | 11–14 | L1 |
| 26 | May 8 | 9:35 p.m. CDT | @ Dodgers | L 2–5 | Honeycutt (2–2) | Tudor (1–4) | Howell (4) | 2:28 | 33,748 | 11–15 | L2 |
| 27 | May 9 | 9:35 p.m. CDT | @ Dodgers | W 5–4 (10) | Allen (1–2) | Howell (2–2) | Dayley (1) | 3:34 | 37,775 | 12–15 | W1 |
| 28 | May 10 | 10:05 p.m. CDT | @ Giants | W 9–3 | Andújar (5–1) | LaPoint (1–5) | Campbell (1) | 2:37 | 12,900 | 13–15 | W2 |
| 29 | May 11 | 3:05 p.m. CDT | @ Giants | W 9–4 | Cox (3–1) | Laskey (1–4) | – | 2:47 | 16,154 | 14–15 | W3 |
| 30 | May 12 | 3:05 p.m. CDT | @ Giants | L 4–5 (10) | Garrelts (2–1) | Allen (1–3) | – | 3:11 | 19,614 | 14–16 | L1 |
| 31 | May 14 | 9:05 p.m. CDT | @ Padres | L 2–6 | Hawkins (7–0) | Tudor (1–5) | Thurmond (1) | 2:31 | 23,904 | 14–17 | L2 |
| 32 | May 15 | 9:05 p.m. CDT | @ Padres | W 14–4 | Andújar (6–1) | Hoyt (2–4) | – | 2:48 | 27,368 | 15–17 | W1 |
| 33 | May 17 | 7:35 p.m. CDT | @ Astros | W 8–6 | Campbell (1–1) | Calhoun (0–1) | Dayley (2) | 2:53 | 14,501 | 16–17 | W2 |
| 34 | May 18 | 7:35 p.m. CDT | @ Astros | L 5–6 | Ryan (3–2) | Kepshire (2–4) | Ross (1) | 2:43 | 39,828 | 16–18 | L1 |
| 35 | May 19 | 2:05 p.m. CDT | @ Astros | L 3–7 | Mathis (3–1) | Tudor (1–6) | Dawley (2) | 2:38 | 15,652 | 16–19 | L2 |
| 36 | May 20 | 7:35 p.m. CDT | Braves | W 14–0 | Andújar (7–1) | Smith (2–3) | – | 2:37 | 25,112 | 17–19 | W1 |
| 37 | May 21 | 7:35 p.m. CDT | Braves | W 6–3 | Cox (4–1) | Barker (1–4) | Horton (1) | 2:40 | 27,541 | 18–19 | W2 |
| 38 | May 22 | 12:35 p.m. CDT | Braves | W 5–3 | Forsch (3–2) | Mahler (8–3) | Dayley (3) | 2:24 | 28,729 | 19–19 | W3 |
| 39 | May 24 | 6:35 p.m. CDT | @ Reds | L 6–7 (12) | Franco (1–1) | Horton (0–1) | – | 3:49 | 20,665 | 19–20 | L1 |
| 40 | May 25 | 6:05 p.m. CDT | @ Reds | W 6–4 | Andújar (8–1) | Tibbs (3–7) | Dayley (4) | 2:50 | 24,846 | 20–20 | W1 |
| 41 | May 26 | 1:15 p.m. CDT | @ Reds | W 7–2 | Cox (5–1) | Stuper (5–3) | – | 2:22 | 21,349 | 21–20 | W2 |
| 42 | May 28 | 6:40 p.m. CDT | @ Braves | W 9–3 | Forsch (4–2) | Smith (2–4) | Lahti (3) | 2:42 | 9,856 | 22–20 | W3 |
| 43 | May 29 | 6:40 p.m. CDT | @ Braves | L 3–5 | Bedrosian (2–3) | Tudor (1–7) | Sutter (9) | 2:22 | 8,557 | 22–21 | L1 |
| 44 | May 30 | 6:40 p.m. CDT | @ Braves | W 6–0 | Andújar (9–1) | Mahler (8–4) | Campbell (2) | 2:25 | 13,503 | 23–21 | W1 |
| 45 | May 31 | 7:35 p.m. CDT | Reds | W 5–0 | Cox (6–1) | Stuper (5–4) | – | 2:05 | 38,910 | 24–21 | W2 |
|
June: 19–8 (Home: 10–4; Away: 9–4)
| # | Date | Time (CT) | Opponent | Score | Win | Loss | Save | Time of Game | Attendance | Record | Box/ Streak |
| 46 | June 1 | 12:20 p.m. CDT | Reds | L 3–9 | Browning (5–4) | Kepshire (2–5) | Hume (2) | 2:53 | 35,586 | 24–22 | L1 |
| 47 | June 2 | 1:15 p.m. CDT | Reds | L 3–8 | Tibbs (4–7) | Forsch (4–3) | – | 2:29 | 33,774 | 24–23 | L2 |
| 48 | June 3 | 7:35 p.m. CDT | Astros | W 9–5 | Tudor (2–7) | Ryan (5–3) | Dayley (5) | 2:35 | 18,891 | 25–23 | W1 |
| 49 | June 4 | 7:35 p.m. CDT | Astros | W 6–1 | Andújar (10–1) | Niekro (2–6) | – | 2:30 | 23,203 | 26–23 | W2 |
| 50 | June 5 | 7:35 p.m. CDT | Astros | L 3–8 | Knepper (6–1) | Cox (6–2) | DiPino (5) | 2:41 | 23,998 | 26–24 | L1 |
| 51 | June 7 | 7:05 p.m. CDT | @ Mets | W 7–2 (13) | Campbell (2–1) | Sisk (1–4) | – | 4:14 | 34,490 | 27–24 | W1 |
| 52 | June 8 | 12:35 p.m. CDT | @ Mets | W 1–0 | Tudor (3–7) | Gorman (3–2) | – | 2:14 | 36,424 | 28–24 | W2 |
| 53 (1) | June 9 | 12:05 p.m. CDT | @ Mets | L 1–6 | Gooden (9–3) | Forsch (4–4) | – | 3:04 | – | 28–25 | L1 |
| 54 (2) | June 9 | 3:44 p.m. CDT | @ Mets | W 8–2 | Andújar (11–1) | Schiraldi (2–1) | – | 2:31 | 41,431 | 29–25 | W1 |
| 55 | June 10 | 6:35 p.m. CDT | @ Pirates | W 6–1 | Cox (7–2) | Rhoden (4–6) | – | 2:16 | 5,557 | 30–25 | W2 |
| 56 | June 11 | 6:35 p.m. CDT | @ Pirates | L 2–13 | Reuschel (3–0) | Allen (1–4) | – | 2:11 | 4,817 | 30–26 | L1 |
| — | June 12 | | @ Pirates | Postponed (Rain) (Makeup date: September 16) |
| 57 | June 13 | 6:35 p.m. CDT | @ Pirates | W 2–1 | Tudor (4–7) | McWilliams (3–5) | Lahti (4) | 1:59 | 4,833 | 31–26 | W1 |
| 58 | June 14 | 3:05 p.m. CDT | @ Cubs | W 11–10 | Andújar (12–1) | Ruthven (3–5) | Forsch (1) | 3:16 | 36,745 | 32–26 | W2 |
| 59 | June 15 | 1:20 p.m. CDT | @ Cubs | W 2–0 | Cox (8–2) | Fontenot (1–2) | – | 2:37 | 34,716 | 33–26 | W3 |
| 60 | June 16 | 1:20 p.m. CDT | @ Cubs | W 5–2 | Kepshire (3–5) | Eckersley (7–4) | Campbell (3) | 2:34 | 36,262 | 34–26 | W4 |
| 61 | June 18 | 7:35 p.m. CDT | Phillies | W 6–2 | Tudor (5–7) | Carlton (1–7) | – | 2:49 | 34,089 | 35–26 | W5 |
| 62 | June 19 | 7:35 p.m. CDT | Phillies | L 0–1 | Koosman (2–1) | Andújar (12–2) | Carman (2) | 2:30 | 32,146 | 35–27 | L1 |
| 63 | June 20 | 7:35 p.m. CDT | Phillies | W 5–0 | Cox (9–2) | Gross (5–7) | – | 2:43 | 32,397 | 36–27 | W1 |
| 64 | June 21 | 7:35 p.m. CDT | Cubs | W 7–5 | Kepshire (4–5) | Eckersley (7–5) | Lahti (5) | 2:45 | 46,005 | 37–27 | W2 |
| 65 | June 22 | 7:05 p.m. CDT | Cubs | W 2–1 (10) | Dayley (1–0) | Smith (3–2) | – | 3:21 | 49,231 | 38–27 | W3 |
| 66 | June 23 | 1:15 p.m. CDT | Cubs | W 7–0 | Tudor (6–7) | Ruthven (3–6) | – | 1:59 | 45,881 | 39–27 | W4 |
| 67 | June 25 | 6:35 p.m. CDT | @ Phillies | L 1–3 | Koosman (3–1) | Andújar (12–3) | – | 2:03 | 24,432 | 39–28 | L1 |
| 68 | June 26 | 6:35 p.m. CDT | @ Phillies | L 4–6 | Denny (5–5) | Cox (9–3) | Tekulve (6) | 2:35 | 22,213 | 39–29 | L2 |
| 69 | June 27 | 2:05 p.m. CDT | @ Phillies | W 4–3 | Kepshire (5–5) | Rawley (5–6) | Lahti (6) | 2:42 | 22,691 | 40–29 | W1 |
| 70 | June 28 | 7:35 p.m. CDT | Mets | W 3–2 | Tudor (7–7) | Lynch (4–5) | Dayley (6) | 2:23 | 45,929 | 41–29 | W2 |
| 71 | June 29 | 7:05 p.m. CDT | Mets | W 6–0 | Andújar (13–3) | Aguilera (1–2) | – | 2:26 | 47,891 | 42–29 | W3 |
| 72 | June 30 | 1:15 p.m. CDT | Mets | W 2–1 (11) | Dayley (2–0) | Orosco (1–4) | – | 3:04 | 47,425 | 43–29 | W4 |
|
July: 17–9 (Home: 8–3; Away: 9–6)
| # | Date | Time (CT) | Opponent | Score | Win | Loss | Save | Time of Game | Attendance | Record | Box/ Streak |
| 73 | July 1 | 12:35 p.m. CDT | @ Expos | L 2–3 (10) | Lucas (3–0) | Horton (0–2) | – | 3:03 | 22,781 | 43–30 | L1 |
| 74 | July 2 | 6:35 p.m. CDT | @ Expos | W 4–0 | Tudor (8–7) | Palmer (6–7) | – | 2:52 | 25,487 | 44–30 | W1 |
| 75 | July 4 | 5:35 p.m. CDT | Dodgers | W 3–2 | Andújar (14–3) | Howell (4–4) | – | 3:05 | 38,394 | 45–30 | W2 |
| 76 | July 5 | 7:35 p.m. CDT | Dodgers | L 1–4 | Niedenfuer (3–2) | Cox (9–4) | Howell (7) | 2:22 | 39,296 | 45–31 | L1 |
| 77 | July 6 | 1:15 p.m. CDT | Dodgers | L 3–8 | Welch (2–1) | Kepshire (5–6) | – | 2:41 | 33,852 | 45–32 | L2 |
| 78 | July 7 | 1:15 p.m. CDT | Dodgers | W 7–1 | Tudor (9–7) | Hershiser (8–3) | – | 2:43 | 36,313 | 46–32 | W1 |
| 79 | July 8 | 7:35 p.m. CDT | Giants | W 6–1 | Andújar (15–3) | LaPoint (3–8) | – | 2:35 | 25,102 | 47–32 | W2 |
| 80 | July 9 | 7:35 p.m. CDT | Giants | W 3–1 | Cox (10–4) | Laskey (1–11) | – | 2:23 | 25,019 | 48–32 | W3 |
| 81 | July 10 | 7:35 p.m. CDT | Giants | W 7–3 | Kepshire (6–6) | | Lahti (7) | 2:38 | 30,196 | 49–32 | W4 |
| 82 | July 11 | 7:35 p.m. CDT | Padres | W 6–0 | Tudor (10–7) | Thurmond (3–7) | – | 2:27 | 32,805 | 50–32 | W5 |
| 83 | July 12 | 7:35 p.m. CDT | Padres | L 0–2 | Hoyt (12–4) | Andújar (15–4) | Gossage (18) | 2:14 | 44,199 | 50–33 | L1 |
| 84 | July 13 | 7:05 p.m. CDT | Padres | W 7–3 | Cox (11–4) | Wojna (1–2) | Lahti (8) | 2:31 | 36,313 | 51–33 | W1 |
| 85 | July 14 | 1:15 p.m. CDT | Padres | W 2–1 | Kepshire (7–6) | Dravecky (8–6) | Lahti (9) | 2:21 | 38,509 | 52–33 | W2 |
| 56th All-Star Game in Minneapolis, MN |
| 86 | July 18 | 9:35 p.m. CDT | @ Dodgers | L 1–2 | Hershiser (9–3) | Campbell (2–2) | Niedenfuer (8) | 2:41 | 46,484 | 52–34 | L1 |
| 87 | July 19 | 9:35 p.m. CDT | @ Dodgers | L 2–5 | Welch (4–1) | Cox (11–5) | – | 2:15 | 49,472 | 52–35 | L2 |
| 88 | July 20 | 9:05 p.m. CDT | @ Dodgers | L 0–3 | Valenzuela (11–8) | Tudor (10–8) | – | 2:09 | 48,582 | 52–36 | L3 |
| 89 | July 21 | 3:05 p.m. CDT | @ Dodgers | W 4–2 (10) | Lahti (1–0) | Niedenfuer (4–3) | Forsch (2) | 3:12 | 40,380 | 53–36 | W1 |
| 90 | July 22 | 3:05 p.m. CDT | @ Giants | W 4–3 | Andújar (16–4) | LaPoint (4–9) | Lahti (10) | 2:43 | 5,954 | 54–36 | W2 |
| 91 | July 23 | 2:05 p.m. CDT | @ Giants | W 6–3 | Cox (12–5) | Krukow (6–8) | – | 2:44 | 7,688 | 55–36 | W3 |
| 92 | July 24 | 3:05 p.m. CDT | @ Giants | W 4–0 | Tudor (11–8) | Gott (4–8) | – | 2:24 | 11,012 | 56–36 | W4 |
| 93 | July 25 | 3:05 p.m. CDT | @ Padres | W 9–6 | Dayley (3–0) | Gossage (2–2) | Lahti (11) | 3:01 | 24,164 | 57–36 | W5 |
| 94 | July 26 | 9:05 p.m. CDT | @ Padres | W 2–1 (12) | Andújar (17–4) | Stoddard (1–5) | Dayley (7) | 3:07 | 28,811 | 58–36 | W6 |
| 95 | July 27 | 9:05 p.m. CDT | @ Padres | L 0–2 | Hawkins (13–3) | Cox (12–6) | Gossage (21) | 2:00 | 32,132 | 58–37 | L1 |
| 96 | July 28 | 3:05 p.m. CDT | @ Padres | W 4–2 | Tudor (11–9) | Hoyt (13–5) | Lahti (12) | 2:27 | 38,762 | 59–37 | W1 |
| 97 | July 30 | 3:05 p.m. CDT | @ Cubs | W 11–3 | Kepshire (8–6) | Engel (0–1) | – | 3:01 | 33,083 | 60–37 | W2 |
| 98 | July 31 | 1:20 p.m. CDT | @ Cubs | L 2–5 | Fontenot (4–5) | Andújar (17–5) | Smith (23) | 2:33 | 31,417 | 60–38 | L1 |
|
August: 17–11 (Home: 7–7; Away: 10–4)
| # | Date | Time (CT) | Opponent | Score | Win | Loss | Save | Time of Game | Attendance | Record | Box/ Streak |
| 99 | August 1 | 1:20 p.m. CDT | @ Cubs | L 8–9 (14) | Frazier (6–4) | Dayley (3–1) | – | 5:03 | 36,164 | 60–39 | L2 |
| 100 | August 2 | 7:35 p.m. CDT | Phillies | W 3–2 | Tudor (12–9) | Hudson (5–9) | – | 2:19 | 47,805 | 61–39 | W1 |
| 101 | August 3 | 7:05 p.m. CDT | Phillies | L 4–6 (10) | Carman (4–3) | Lahti (1–1) | Andersen (3) | 3:04 | 47,051 | 61–40 | L1 |
| 102 | August 4 | 1:15 p.m. CDT | Phillies | L 0–6 | Gross (11–8) | Andújar (17–6) | – | 2:25 | 46,674 | 61–41 | L2 |
| 103 | August 5 | 7:35 p.m. CDT | Phillies | L 1–9 | Rawley (8–6) | Cox (12–7) | – | 2:15 | 36,689 | 61–42 | L3 |
| — | August 6 | | Cubs | Postponed (Strike) (Makeup date: September 9) |
| — | August 7 | | Cubs | Postponed (Strike) (Makeup date: September 5) |
| 104 | August 8 | 7:35 p.m. CDT | Cubs | W 8–0 | Tudor (14–8) | Sanderson (5–5) | – | 2:18 | 39,203 | 62–42 | W1 |
| 105 | August 9 | 7:05 p.m. CDT | @ Phillies | W 5–4 | Andújar (18–6) | Hudson (5–10) | Lahti (13) | 2:36 | 25,194 | 63–42 | W2 |
| 106 (1) | August 10 | 4:35 p.m. CDT | @ Phillies | W 5–4 | Cox (13–7) | Koosman (6–3) | Lahti (14) | 2:31 | – | 64–42 | W3 |
| 107 (2) | August 10 | 7:41 p.m. CDT | @ Phillies | W 13–4 | Horton (1–2) | Gross (11–9) | – | 3:02 | 37,321 | 65–42 | W4 |
| 108 | August 11 | 12:35 p.m. CDT | @ Phillies | L 1–4 | Rawley (9–6) | Forsch (4–5) | – | 2:02 | 31,602 | 65–43 | L1 |
| 109 | August 12 | 7:35 p.m. CDT | Pirates | W 8–1 | Tudor (15–8) | Winn (2–5) | – | 3:07 | 24,516 | 66–43 | W1 |
| 110 | August 13 | 7:35 p.m. CDT | Pirates | W 6–5 | Andújar (19–6) | Robinson (2–8) | Dayley (8) | 2:54 | 30,469 | 67–43 | W2 |
| — | August 14 | | Pirates | Postponed (Rain) (Makeup date: August 15) |
| 111 (1) | August 15 | 12:35 p.m. CDT | Pirates | W 3–1 | Kepshire (9–6) | Reuschel (8–6) | Dayley (9) | 2:10 | – | 68–43 | W3 |
| 112 (2) | August 15 | 3:20 p.m. CDT | Pirates | W 4–3 (12) | Campbell (3–2) | Guante (3–5) | – | 4:14 | 34,170 | 69–43 | W4 |
| 113 | August 16 | 7:35 p.m. CDT | Expos | W 6–1 | Forsch (5–5) | Laskey (5–12) | – | 2:26 | 40,873 | 70–43 | W5 |
| 114 | August 17 | 7:05 p.m. CDT | Expos | L 4–5 | Burke (8–0) | Campbell (3–3) | Lucas (1) | 2:55 | 45,093 | 70–44 | L1 |
| 115 | August 18 | 1:15 p.m. CDT | Expos | L 5–6 (10) | Lucas (4–2) | Andújar (19–7) | Reardon (31) | 3:20 | 39,813 | 70–45 | L2 |
| 116 | August 20 | 7:35 p.m. CDT | @ Astros | L 2–17 | Scott (13–6) | Kepshire (9–7) | – | 2:27 | 10,348 | 70–46 | L3 |
| 117 | August 21 | 7:35 p.m. CDT | @ Astros | W 7–4 | Lahti (2–1) | Smith (6–5) | – | 2:53 | 14,164 | 71–46 | W1 |
| 118 | August 22 | 7:35 p.m. CDT | @ Astros | W 2–1 | Horton (2–2) | Calhoun (1–2) | Dayley (10) | 2:43 | 14,555 | 71–47 | W2 |
| 119 | August 23 | 6:40 p.m. CDT | @ Braves | W 6–2 | Andújar (20–7) | McMurtry (0–3) | Lahti (15) | 2:51 | 19,958 | 72–47 | W3 |
| 120 | August 24 | 6:40 p.m. CDT | @ Braves | W 7–0 (6) | Forsch (6–5) | Barker (1–6) | – | 1:40 | 31,109 | 73–47 | W4 |
| 121 | August 25 | 1:10 p.m. CDT | @ Braves | W 5–2 | Kepshire (10–7) | Mahler (16–12) | Campbell (4) | 2:39 | 14,711 | 74–47 | W5 |
| 122 | August 26 | 6:35 p.m. CDT | @ Reds | W 3–0 | Cox (14–7) | Tibbs (6–15) | – | 2:16 | 28,071 | 76–46 | W6 |
| 123 | August 27 | 6:35 p.m. CDT | @ Reds | W 6–4 | Campbell (4–3) | Power (4–4) | Lahti (16) | 2:50 | 22,268 | 77–46 | W7 |
| 124 | August 28 | 6:35 p.m. CDT | @ Reds | L 6–7 (12) | Power (5–4) | Lahti (2–2) | – | 4:13 | 21,049 | 77–47 | L1 |
| 125 | August 30 | 7:35 p.m. CDT | Astros | L 5–7 | Scott (13–6) | Kepshire (14–7) | Smith (20) | 2:39 | 31,975 | 77–48 | L2 |
| 126 | August 31 | 7:05 p.m. CDT | Astros | L 1–3 | Knepper (11–10) | Cox (14–8) | – | 2:29 | 38,387 | 77–49 | L3 |
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September: 21–9 (Home: 12–4; Away: 9–5)
| # | Date | Time (CT) | Opponent | Score | Win | Loss | Save | Time of Game | Attendance | Record | Box/ Streak |
| 127 | September 1 | 1:15 p.m. CDT | Astros | W 5–0 | Tudor (16–8) | Niekro (9–11) | – | 2:34 | 31,927 | 78–49 | W1 |
| 128 | September 2 | 5:35 p.m. CDT | Reds | L 1–4 | Browning (15–9) | Andújar (20–8) | Franco (9) | 2:15 | 29,026 | 78–50 | L1 |
| 129 | September 3 | 7:35 p.m. CDT | Reds | W 6–4 | Lahti (3–2) | Hume (2–4) | – | 2:43 | 19,261 | 79–50 | W1 |
| 130 | September 4 | 7:35 p.m. CDT | Reds | W 4–3 | Worrell (1–0) | Robinson (5–4) | – | 2:33 | 25,425 | 80–50 | W2 |
| 131 | September 5 | 7:35 p.m. CDT | Cubs | W 6–1 | Cox (15–8) | Engel (1–3) | – | 2:21 | 33,693 | 81–50 | W3 |
| 132 | September 6 | 7:35 p.m. CDT | Braves | W 8–0 | Tudor (17–8) | Mahler (17–14) | – | 2:41 | 25,821 | 82–50 | W4 |
| 133 | September 7 | 7:05 p.m. CDT | Braves | L 1–3 | Bedrosian (6–11) | Andújar (20–9) | Sutter (22) | 2:30 | 38,091 | 82–51 | L1 |
| 134 | September 8 | 1:15 p.m. CDT | Braves | L 3–7 | Johnson (4–0) | Forsch (6–6) | – | 2:48 | 24,930 | 82–52 | L2 |
| 135 | September 9 | 7:35 p.m. CDT | Cubs | L 1–3 | Fontenot (6–8) | Kepshire (10–9) | Meridith (1) | 3:00 | 32,808 | 82–53 | L3 |
| 136 | September 10 | 6:35 p.m. CDT | @ Mets | L 4–5 | Darling (15–5) | Cox (15–9) | McDowell (13) | 2:34 | 50,195 | 82–54 | L4 |
| 137 | September 11 | 6:35 p.m. CDT | @ Mets | W 1–0 (10) | Tudor (18–6) | Orosco (5–5) | – | 3:03 | 52,616 | 83–54 | W1 |
| 138 | September 12 | 12:35 p.m. CDT | @ Mets | L 6–7 | Orosco (6–5) | Dayley (3–2) | – | 3:16 | 46,295 | 83–55 | L1 |
| 139 | September 13 | 1:20 p.m. CDT | @ Cubs | W 9–3 | Forsch (7–6) | Trout (8–5) | Worrell (1) | 3:10 | 16,110 | 84–55 | W1 |
| 140 | September 14 | 1:20 p.m. CDT | @ Cubs | W 5–4 | Campbell (5–3) | Sorensen (5–3) | Lahti (17) | 3:05 | 29,852 | 85–55 | W2 |
| 141 | September 15 | 1:20 p.m. CDT | @ Cubs | W 5–1 | Cox (16–8) | Engel (1–5) | – | 2:58 | 28,430 | 86–55 | W3 |
| 142 (1) | September 16 | 12:35 p.m. CDT | @ Pirates | W 8–4 | Tudor (19–8) | DeLeón (2–18) | Worrell (2) | 3:19 | – | 87–55 | W4 |
| 143 (2) | September 16 | 4:29 p.m. CDT | @ Pirates | W 3–1 | Perry (1–0) | Clements (0–2) | – | 2:51 | 3,601 | 88–55 | W5 |
| 144 | September 17 | 6:35 p.m. CDT | @ Pirates | W 10–4 | Andújar (21–9) | Kipper (0–1) | – | 2:56 | 3,924 | 89–55 | W6 |
| 145 | September 18 | 6:35 p.m. CDT | @ Phillies | W 7–0 | Forsch (8–6) | Denny (11–12) | – | 2:36 | 17,354 | 90–55 | W7 |
| 146 | September 19 | 6:35 p.m. CDT | @ Phillies | L 3–6 | Rucker (3–1) | Keough (0–1) | Carman (6) | 2:44 | 17,120 | 90–56 | L1 |
| 147 | September 20 | 7:35 p.m. CDT | Expos | W 5–3 | Worrell (2–0) | St. Claire (4–3) | – | 2:27 | 33,788 | 91–56 | W1 |
| 148 | September 21 | 12:20 p.m. CDT | Expos | W 7–6 | Lahti (4–2) | Roberge (3–3) | Worrell (3) | 3:00 | 32,788 | 92–56 | W2 |
| 149 | September 22 | 1:15 p.m. CDT | Expos | W 6–5 | Dayley (4–2) | O'Connor (0–2) | – | 3:09 | 32,958 | 93–56 | W3 |
| 150 | September 23 | 7:35 p.m. CDT | Pirates | W 5–4 | Lahti (5–2) | Guante (4–6) | Worrell (4) | 2:55 | 17,611 | 94–56 | W4 |
| 151 | September 24 | 7:35 p.m. CDT | Pirates | W 5–4 | Horton (3–2) | Tunnell (4–10) | Dayley (11) | 2:56 | 20,054 | 95–56 | W5 |
| 152 | September 25 | 7:35 p.m. CDT | Phillies | W 6–3 | Cox (17–9) | Hudson (7–13) | Lahti (18) | 2:46 | 17,733 | 96–56 | W6 |
| 153 | September 26 | 7:35 p.m. CDT | Phillies | W 5–0 | Tudor (20–8) | Gross (14–12) | – | 2:19 | 23,598 | 97–56 | W7 |
| — | September 27 | | @ Expos | Postponed (Rain) (Makeup date: September 28) |
| 154 (1) | September 28 | 2:20 p.m. CDT | @ Expos | L 0–2 | Gullickson (14–11) | Andújar (21–10) | Reardon (37) | 2:24 | – | 97–57 | L1 |
| 155 (2) | September 28 | 5:19 p.m. CDT | @ Expos | W 4–2 (11) | Worrell (3–0) | Reardon (2–8) | – | 3:21 | 15,512 | 98–57 | W1 |
| 156 | September 29 | 12:35 p.m. CDT | @ Expos | L 5–7 | Lucas (6–2) | Dayley (4–3) | Reardon (38) | 2:40 | 20,577 | 98–58 | L1 |
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October: 3–3 (Home: 3–3; Away: 0–0)
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| *An MLB Players strike forced the cancellation of all regular season games on August 6 and 7. Most games were made up later in the season. |
Legend: = Win = Loss = Postponement = Clinched Bold = Cardinals team member |