The 1981 Southern League was a Class AA baseball season played between April 9 and September 1. Ten teams played a 144-game schedule, with the top team in each division in each half of the season qualifying for the post-season.
The Orlando Twins won the Southern League championship, as they defeated the Nashville Sounds in the playoffs.
Teams
| 1981 Southern League |
| Division | Team | City | MLB Affiliate | Stadium |
| East |
Charlotte Orioles |
Charlotte, North Carolina |
Baltimore Orioles |
Jim Crockett Memorial Park |
| Columbus Astros |
Columbus, Georgia |
Houston Astros |
Golden Park |
| Jacksonville Suns |
Jacksonville, Florida |
Kansas City Royals |
Wolfson Park |
| Orlando Twins |
Orlando, Florida |
Minnesota Twins |
Tinker Field |
| Savannah Braves |
Savannah, Georgia |
Atlanta Braves |
Grayson Stadium |
| West |
Birmingham Barons |
Birmingham, Alabama |
Detroit Tigers |
Rickwood Field |
| Chattanooga Lookouts |
Chattanooga, Tennessee |
Cleveland Indians |
Engel Stadium |
| Knoxville Blue Jays |
Knoxville, Tennessee |
Toronto Blue Jays |
Bill Meyer Stadium |
| Memphis Chicks |
Memphis, Tennessee |
Montreal Expos |
Tim McCarver Stadium |
| Nashville Sounds |
Nashville, Tennessee |
New York Yankees |
Herschel Greer Stadium |
Map of teams

East Division

West Division
Regular season
Summary
- The Nashville Sounds finished the season with the best record in the league for the second consecutive season.