| 1961 Game Log: 109–53–1 (Home: 65–16; Away: 44–37–1)[7] |
April: 9–5 (Home: 6–1; Away: 3–4)
| # | Date | Time (ET) | Opponent | Score | Win | Loss | Save | Time of Game | Attendance | Record | Box/ Streak |
| 1 | April 11 | | Twins | 6–0 | Ramos (1–0) | Ford (0–1) | | | 14,607 | 0–1 | |
| 2 | April 15 | | Athletics | 5–3 | Turley (1–0) | Daley (0–1) | Stafford (1) | | 11,802 | 1–1 | |
| 3 | April 17 | | Athletics | 3–0 | Ford (1–1) | Walker (0–1) | | | 1,947 | 2–1 | |
| 4 | April 20 | | Angels | 7–5 | Ditmar (1–0) | Grba (0–1) | Stafford (2) | | | 3–1 | |
| 5 | April 20 | | Angels | 4–2 | Turley (2–0) | Garver (0–1) | Arroyo (1) | | 7,059 | 4–1 | |
| 6 | | 8:00 p.m. EST | @ Orioles | W 4–2 | Ford (2–1) | Barber (1–1) | — | 2:17 | 12,368 | 5–1 | W5 |
| 7 (1) | | 2:00 p.m. EST | @ Orioles | L 3–5 | Wilhelm (1–0) | Duren (0–1) | — | 2:17 | 12,536 | 5–2 | L1 |
| 8 (2) | | 8:00 p.m. EST | @ Orioles | T 5–5 (7) | — | — | — | 2:09 | 14,126 | 5–2 | T1 |
| 9 | | 2:00 p.m. EST | @ Orioles | L 1–4 | Estrada (1–1) | McDevitt (0–1) | Hall (1) | 2:40 | 18,704 | 5–3 | L1 |
| 10 | | 1:30 p.m. EST | @ Tigers | L 3–4 | Lary (3–0) | Turley (2–1) | — | 2:19 | 5,662 | 5–4 | L2 |
| — | | 1:30 p.m. EST | @ Tigers | Postponed (Rain) (Makeup date: September 15) |
| 11 | | 8:15 p.m. EST | @ Tigers | W 13–11 (10) | Arroyo (1–0) | Aguirre (0–1) | — | 3:20 | 4,676 | 6–4 | W1 |
| 12 | April 27 | | Indians | 4–3 | Ditmar (2–0) | Antonelli (0–2) | | | 8,897 | 7–4 | |
| 13 | April 29 | | Indians | 4–2 | Terry (1–0) | Perry (2–1) | Arroyo (2) | | 14,624 | 8–4 | |
| 14 | April 30 | | @ Senators | 4–3 | Ford (3–1) | Donovan (0–4) | Arroyo (3) | | | 9–4 | |
| 15 | April 30 | | @ Senators | 2–1 | Woodeshick (1–1) | Sheldon (0–1) | Burnside (1) | | 21,904 | 9–5 | |
|
May: 14–12 (Home: 7–6; Away: 7–6)
| # | Date | Time (ET) | Opponent | Score | Win | Loss | Save | Time of Game | Attendance | Record | Box/ Streak |
| 16 | May 2 | | @ Twins | 6 – 4 (10) | Coates (1–0) | Pascual (2–1) | Arroyo (4) | | 16,669 | 10–5 | |
| 17 | May 3 | | @ Twins | 7–3 | Turley (3–1) | Ramos (2–1) | | | 18,158 | 11–5 | |
| 18 | May 4 | | @ Twins | 5–2 | Ford (4–1) | Kaat (1–2) | Coates (1) | | 18,179 | 12–5 | |
| 19 | May 5 | | @ Angels | 5–4 | McDevitt (1–1) | Clevenger (2–1) | Arroyo (5) | | 17,801 | 13–5 | |
| 20 | May 6 | | @ Angels | 5–3 | Grba (2–2) | Ditmar (2–1) | | | 19,865 | 13–6 | |
| 21 | May 7 | | @ Angels | 5–3 | Kline (1–0) | Coates (1–1) | Clevenger (1) | | 19,722 | 13–7 | |
| 22 | May 9 | | @ Athletics | 5–4 | Herbert (2–1) | Arroyo (1–1) | Archer (1) | | 13,623 | 13–8 | |
| 23 | May 10 | | @ Athletics | 9–4 | Clevenger (3–1) | Daley (3–4) | | | 15,986 | 14–8 | |
| 24 | | 8:00 p.m. EST | Tigers | L 3–4 | Lary (5–1) | Coates (1–2) | — | 3:09 | 23,556 | 14–9 | L1 |
| 25 | | 2:00 p.m. EST | Tigers | L 3–8 | Regan (3–0) | Turley (3–2) | — | 2:45 | 18,036 | 14–10 | L2 |
| 26 (1) | | 2:00 p.m. EST | Tigers | W 5–4 (11) | Coates (2–2) | Aguirre (1–2) | — | 3:30 | — | 15–10 | W1 |
| 27 (2) | | 5:55 p.m. EST | Tigers | W 8–6 | Coates (3–2) | Bunning (2–3) | — | 2:39 | 40,968 | 16–10 | W2 |
| 28 | May 16 | | Senators | 3–2 | Woodeshick (2–1) | Stafford (0–1) | Sisler (5) | | 10,050 | 16–11 | |
| 29 | May 17 | | Senators | 8–7 | Burnside (1–2) | Ditmar (2–2) | Gabler (1) | | 6,197 | 16–12 | |
| 30 | May 19 | | @ Indians | 9–7 | Latman (3–0) | Clevenger (3–2) | Allen (2) | | 21,240 | 16–13 | |
| 31 | May 20 | | @ Indians | 4–3 | Funk (4–2) | Stafford (0–2) | | | 8,431 | 16–14 | |
| 32 (1) | | 2:00 p.m. EST | Orioles | W 4–2 | Ford (5–1) | Estrada (2–3) | — | 2:22 | — | 17–14 | W1 |
| 33 (2) | | 4:47 p.m. EST | Orioles | L 2–3 | Barber (5–3) | Sheldon (0–2) | Wilhelm (5) | 2:37 | 47,890 | 17–15 | L1 |
| 34 | | 8:00 p.m. EST | Orioles | W 8–2 | Coates (4–2) | Fisher (1–5) | Arroyo (6) | 2:43 | 16,923 | 18–15 | W1 |
| 35 | May 24 | | Red Sox | 3–2 | Terry (2–0) | Nichols (0–1) | | | 7,673 | 19–15 | |
| 36 | May 25 | | Red Sox | 6–4 | Ford (6–1) | Muffett (0–4) | Arroyo (7) | | 13,087 | 20–15 | |
| 37 | May 28 | | White Sox | 14–9 | Lown (2–2) | Arroyo (1–2) | Pierce (2) | | | 20–16 | |
| 38 | May 28 | | White Sox | 5–3 | Coates (5–2) | McLish (2–5) | | | 44,435 | 21–16 | |
| 39 | May 29 | | @ Red Sox | 2–1 | Delock (3–1) | Ford (6–2) | | | 21,804 | 21–17 | |
| 40 | May 30 | | @ Red Sox | 12–3 | Stafford (1–2) | Conley (2–4) | Coates (2) | | 19,582 | 22–17 | |
| 41 | May 31 | | @ Red Sox | 7–6 | Sheldon (1–2) | Muffett (0–5) | McDevitt (1) | | 17,318 | 23–17 | |
|
June: 22–10 (Home: 10–1; Away: 12–9)
| # | Date | Time (ET) | Opponent | Score | Win | Loss | Save | Time of Game | Attendance | Record | Box/ Streak |
| 42 | June 1 | | @ Red Sox | 7–5 | Monbouquette (4–5) | Turley (3–3) | Stallard (1) | | 5,257 | 23–18 | |
| 43 | June 2 | | @ White Sox | 6–2 | Ford (7–2) | McLish (2–6) | | | 38,410 | 24–18 | |
| 44 | June 3 | | @ White Sox | 6 – 5 (13) | Hacker (1–0) | Ditmar (2–3) | | | 16,480 | 24–19 | |
| 45 | June 4 | | @ White Sox | 10–1 | Stafford (2–2) | Pierce (1–5) | | | 28,362 | 25–19 | |
| 46 | June 5 | | Twins | 6–2 | Coates (6–2) | Lee (0–2) | Arroyo (8) | | | 26–19 | |
| 47 | June 5 | | Twins | 6–1 | Sheldon (2–2) | Stobbs (0–2) | | | 23,103 | 27–19 | |
| 48 | June 6 | | Twins | 7–2 | Ford (8–2) | Kralick (4–4) | Arroyo (9) | | 17,129 | 28–19 | |
| 49 | June 7 | | Twins | 5–1 | Terry (3–0) | Ramos (3–7) | | | 9,016 | 29–19 | |
| 50 | June 8 | | Athletics | 6–1 | Stafford (3–2) | Bass (4–3) | | | | 30–19 | |
| 51 | June 8 | | Athletics | 9–6 | Archer (3–1) | McDevitt (1–2) | | | 13,157 | 30–20 | |
| 52 | June 9 | | Athletics | 8–6 | Arroyo (2–2) | Herbert (3–6) | | | 22,418 | 31–20 | |
| 53 | June 10 | | Athletics | 5–3 | Ford (9–2) | Nuxhall (4–2) | | | 17,272 | 32–20 | |
| 54 | June 11 | | Angels | 2–1 | Terry (4–0) | McBride (5–4) | | | | 33–20 | |
| 55 | June 11 | | Angels | 5–1 | Sheldon (3–2) | Grba (5–5) | Arroyo (10) | | 37,378 | 34–20 | |
| 56 | June 12 | | Angels | 3–1 | Stafford (4–2) | Bowsfield (2–2) | | | 16,363 | 35–20 | |
| 57 | June 13 | | @ Indians | 7–2 | Perry (5–4) | Coates (6–3) | Funk (5) | | 21,704 | 35–21 | |
| 58 | June 14 | | @ Indians | 11–5 | Ford (10–2) | Bell (4–6) | Arroyo (11) | | 25,095 | 36–21 | |
| 59 | June 15 | | @ Indians | 3 – 2 (11) | Terry (5–0) | Funk (7–5) | | | 23,350 | 37–21 | |
| 60 | | 8:15 p.m. EST | @ Tigers | L 2–4 | Regan (7–2) | Stafford (4–3) | — | 2:12 | 51,744 | 37–22 | L1 |
| 61 | | 8:15 p.m. EST | @ Tigers | L 10–12 | Foytack (4–4) | Daley (4–9) | Fox (4) | 2:58 | 51,509 | 37–23 | L2 |
| 62 | | 1:300 p.m. EST | @ Tigers | W 9–0 | Ford (11–2) | Lary (10–4) | Arroyo (12) | 2:27 | 44,459 | 38–23 | W1 |
| 63 | June 19 | | @ Athletics | 4–3 | Archer (5–1) | Arroyo (2–3) | | | 16,715 | 38–24 | |
| 64 | June 20 | | @ Athletics | 6–2 | Stafford (5–3) | Nuxhall (4–3) | Coates (3) | | 19,928 | 39–24 | |
| 65 | June 21 | | @ Athletics | 5–3 | Daley (5–9) | Shaw (3–6) | Arroyo (13) | | 19,416 | 40–24 | |
| 66 | June 22 | | @ Athletics | 8–3 | Ford (12–2) | Bass (4–6) | Arroyo (14) | | 17,254 | 41–24 | |
| 67 | June 23 | | @ Twins | 4–0 | Pascual (5–9) | Turley (3–4) | | | 30,940 | 41–25 | |
| 68 | June 24 | | @ Twins | 10–7 | Sheldon (4–2) | Cueto (0–2) | Arroyo (15) | | 35,199 | 42–25 | |
| 69 | June 25 | | @ Twins | 8–4 | Stafford (6–3) | Kralick (6–5) | Coates (4) | | 35,152 | 43–25 | |
| 70 | June 26 | | @ Angels | 8–6 | Ford (13–2) | Donohue (1–2) | Arroyo (16) | | 18,870 | 44–25 | |
| 71 | June 27 | | @ Angels | 7–6 | Bowsfield (4–2) | Daley (5–10) | Grba (2) | | 16,108 | 44–26 | |
| 72 | June 28 | | @ Angels | 5–3 | Duren (3–8) | Turley (3–5) | Donohue (3) | | 14,674 | 44–27 | |
| 73 | June 30 | | @ Senators | 5–1 | Ford (14–2) | Donovan (3–8) | | | 28,019 | 45–27 | |
|
July: 20–9 (Home: 11–5; Away: 9–4)
| # | Date | Time (ET) | Opponent | Score | Win | Loss | Save | Time of Game | Attendance | Record | Box/ Streak |
| 74 | July 1 | | @ Senators | 7–6 | Arroyo (3–3) | Sisler (1–3) | | | 16,015 | 46–27 | |
| 75 | July 2 | | @ Senators | 13–4 | Daley (6–10) | Burnside (1–5) | Arroyo (17) | | 19,794 | 47–27 | |
| 76 (1) | | 1:30 p.m. EST | Tigers | W 6–2 | Ford (15–2) | Mossi (9–2) | — | 2:20 | — | 48–27 | W4 |
| 77 (2) | | 4:15 p.m. EST | Tigers | L 3–4 (10) | Lary (12–4) | Stafford (6–4) | Fox (6) | 3:29 | 74,246 | 48–28 | L1 |
| 78 | July 5 | | Indians | 6–0 | Sheldon (5–2) | Bell (5–9) | | | 24,377 | 49–28 | |
| 79 | July 6 | | Indians | 4–0 | Stafford (7–4) | Stigman (2–2) | | | 37,136 | 50–28 | |
| 80 | July 7 | | Red Sox | 14–3 | Daley (7–10) | Conley (3–7) | | | 29,199 | 51–28 | |
| 81 | July 8 | | Red Sox | 8–5 | Ford (16–2) | Delock (5–5) | Arroyo (18) | | 23,381 | 52–28 | |
| 82 | July 9 | | Red Sox | 3–0 | Sheldon (6–2) | Monbouquette (8–7) | | | | 53–28 | |
| 83 | July 9 | | Red Sox | 9–6 | Schwall (7–2) | Terry (5–1) | Earley (1) | | 47,875 | 53–29 | |
| — | | | 30th All-Star Game in San Francisco, CA |
| 84 | July 13 | | @ White Sox | 6–2 | Stafford (8–4) | Wynn (7–2) | Arroyo (19) | | 43,960 | 54–29 | |
| 85 | July 14 | | @ White Sox | 6–1 | Pizarro (5–3) | Sheldon (6–3) | | | 43,450 | 54–30 | |
| 86 | July 15 | | @ White Sox | 9 – 8 (10) | Arroyo (4–3) | Hacker (2–2) | | | 37,730 | 55–30 | |
| 87 | | 2:00 p.m. EST | @ Orioles | W 2–1 | Daley (8–10) | Barber (10–7) | — | 2:10 | 38,487 | 56–30 | W2 |
| 88 | | 8:00 p.m. EST | @ Orioles | W 5–0 | Ford (17–2) | Pappas (6–5) | — | 2:18 | 44,332 | 57–30 | W3 |
| 89 | July 18 | | @ Senators | 5–3 | Arroyo (5–3) | McClain (7–9) | | | 17,695 | 58–30 | |
| 90 | July 19 | | @ Senators | 8–4 | Daniels (5–5) | Daley (8–11) | | | | 58–31 | |
| 91 | July 19 | | @ Senators | 12–2 | Donovan (6–8) | Downing (0–1) | | | 27,176 | 58–32 | |
| 92 | July 21 | | @ Red Sox | 11–8 | Arroyo (6–3) | Earley (1–4) | | | 32,186 | 59–32 | |
| 93 | July 22 | | @ Red Sox | 11–9 | Arroyo (7–3) | Conley (4–9) | | | 25,089 | 60–32 | |
| 94 | July 23 | | @ Red Sox | 5–4 | Schwall (10–2) | Daley (8–12) | | | 28,575 | 60–33 | |
| 95 | July 25 | | White Sox | 5–1 | Ford (18–2) | Baumann (7–8) | Arroyo (20) | | | 61–33 | |
| 96 | July 25 | | White Sox | 12–0 | Stafford (9–4) | Pizarro (6–4) | | | 46,240 | 62–33 | |
| 97 | July 26 | | White Sox | 5–2 | Sheldon (7–3) | Herbert (7–9) | | | 22,366 | 63–33 | |
| 98 | July 27 | | White Sox | 4–3 | Terry (6–1) | Pierce (5–7) | Arroyo (21) | | 20,529 | 64–33 | |
| 99 | | 8:00 p.m. EST | Orioles | L 0–4 | Brown (8–3) | Daley (8–13) | — | 2:00 | 39,623 | 64–34 | L1 |
| 100 | | 2:00 p.m. EST | Orioles | W 5–4 | Ford (19–2) | Fisher (4–10) | — | 2:08 | 42,990 | 65–34 | W1 |
| 101 (1) | | 2:00 p.m. EST | Orioles | L 0–4 | Barber (12–8) | Stafford (9–5) | — | 2:30 | — | 65–35 | L1 |
| 102 (2) | | 4:55 p.m. EST | Orioles | L 1–2 | Pappas (7–6) | Daley (8–14) | Hall (3) | 2:53 | 57,180 | 65–36 | L2 |
| — | | | 31st All-Star Game in Boston, MA |
|
August: 22–9 (Home: 7–9; Away: 7–5)
| # | Date | Time (ET) | Opponent | Score | Win | Loss | Save | Time of Game | Attendance | Record | Box/ Streak |
| 103 | August 2 | | Athletics | 6–5 | Arroyo (8–3) | Archer (7–6) | | | | 66–36 | |
| 104 | August 2 | | Athletics | 12–5 | Terry (7–1) | Ditmar (2–6) | Reniff (1) | | 23,616 | 67–36 | |
| 105 | August 3 | | Athletics | 6–1 | Shaw (7–9) | Daley (8–15) | | | 12,584 | 67–37 | |
| 106 | August 4 | | Twins | 8 – 5 (10) | Arroyo (9–3) | Pleis (3–2) | | | 24,109 | 68–37 | |
| 107 | August 5 | | Twins | 2–1 | Coates (7–3) | Kralick (10–7) | | | 18,880 | 69–37 | |
| 108 | August 6 | | Twins | 7 – 6 (15) | Reniff (1–0) | Moore (4–4) | | | | 70–37 | |
| 109 | August 6 | | Twins | 3–2 | Sheldon (8–3) | Schroll (0–1) | | | 39,408 | 71–37 | |
| 110 | August 7 | | Angels | 4–1 | Daley (9–15) | McBride (9–8) | | | 13,944 | 72–37 | |
| 111 | August 8 | | Angels | 5 – 4 (10) | Arroyo (10–3) | Fowler (5–5) | | | 24,084 | 73–37 | |
| 112 | August 9 | | Angels | 2–0 | Coates (8–3) | Bowsfield (8–4) | | | 17,261 | 74–37 | |
| 113 | August 10 | | Angels | 3–1 | Ford (20–2) | Donohue (4–5) | Arroyo (22) | | 15,575 | 75–37 | |
| 114 | August 11 | | @ Senators | 12–5 | Terry (8–1) | McClain (7–13) | Reniff (2) | | 22,601 | 76–37 | |
| 115 | August 12 | | @ Senators | 5–1 | Donovan (8–8) | Stafford (9–6) | | | 15,870 | 76–38 | |
| 116 | August 13 | | @ Senators | 12–2 | Daniels (7–6) | Daley (9–16) | | | | 76–39 | |
| 117 | August 13 | | @ Senators | 9–4 | Coates (9–3) | Kutyna (6–4) | | | 27,368 | 77–39 | |
| 118 | August 15 | | White Sox | 2–1 | Pizarro (8–5) | Ford (20–3) | | | 49,059 | 77–40 | |
| 119 | August 16 | | White Sox | 5–4 | Terry (9–1) | Lown (6–5) | | | 29,728 | 78–40 | |
| 120 | August 17 | | White Sox | 5–3 | Stafford (10–6) | Baumann (9–10) | Arroyo (23) | | 25,532 | 79–40 | |
| 121 | August 18 | | @ Indians | 5–1 | Grant (12–6) | Coates (9–4) | | | 37,840 | 79–41 | |
| 122 | August 19 | | @ Indians | 3 – 2 (10) | Ford (21–3) | Locke (4–2) | Arroyo (24) | | 23,398 | 80–41 | |
| 123 | August 20 | | @ Indians | 6–0 | Terry (10–1) | Perry (9–11) | | | | 81–41 | |
| 124 | August 20 | | @ Indians | 5–2 | Sheldon (9–3) | Bell (8–13) | | | 56,307 | 82–41 | |
| 125 | August 22 | | @ Angels | 4–3 | McBride (10–10) | Stafford (10–7) | | | 19,930 | 82–42 | |
| 126 | August 23 | | @ Angels | 8 – 6 (10) | Arroyo (11–3) | Donohue (4–6) | | | 19,773 | 83–42 | |
| 127 | August 24 | | @ Angels | 6–4 | Morgan (6–2) | Coates (9–5) | | | 19,819 | 83–43 | |
| 128 | August 25 | | @ Athletics | 3–0 | Terry (11–1) | Archer (8–10) | | | 30,830 | 84–43 | |
| 129 | August 26 | | @ Athletics | 5–1 | Stafford (11–7) | Walker (5–11) | | | 32,149 | 85–43 | |
| 130 | August 27 | | @ Athletics | 8–7 | Ford (22–3) | Shaw (8–12) | Arroyo (25) | | 34,065 | 86–43 | |
| 131 | August 29 | | @ Twins | 3–0 | Pascual (12–13) | Terry (11–2) | | | 40,118 | 86–44 | |
| 132 | August 30 | | @ Twins | 4–0 | Stafford (12–7) | Kaat (7–13) | | | 41,357 | 87–44 | |
| 133 | August 31 | | @ Twins | 5–4 | Kralick (12–9) | Sheldon (9–4) | | | 33,709 | 87–45 | |
|
September: 21–8 (Home: 15–1; Away: 6–7)
| # | Date | Time (ET) | Opponent | Score | Win | Loss | Save | Time of Game | Attendance | Record | Box/ Streak |
| 134 | | 8:00 p.m. EST | Tigers | W 1–0 | Arroyo (12–3) | Mossi (14–4) | — | 2:44 | 65,566 | 88–45 | W1 |
| 135 | | 2:00 p.m. EST | Tigers | W 7–2 | Terry (12–2) | Lary (19–8) | Arroyo (26) | 2:02 | 50,261 | 89–45 | W2 |
| 136 | | 2:00 p.m. EST | Tigers | W 8–5 | Arroyo (13–3) | Staley (2–5) | — | 2:42 | 55,676 | 90–45 | W3 |
| 137 | September 4 | | Senators | 5–3 | Reniff (2–0) | Daniels (8–10) | | | | 91–45 | |
| 138 | September 4 | | Senators | 3–2 | Daley (10–16) | Burnside (1–7) | | | 34,683 | 92–45 | |
| 139 | September 5 | | Senators | 6–1 | Coates (10–5) | McClain (8–16) | | | 16,917 | 93–45 | |
| 140 | September 6 | | Senators | 8–0 | Ford (23–3) | Cheney (1–3) | | | 12,295 | 94–45 | |
| 141 | September 7 | | Indians | 7–3 | Terry (13–2) | Stigman (2–4) | | | 18,549 | 95–45 | |
| 142 | September 8 | | Indians | 9–1 | Stafford (13–7) | Bell (9–15) | | | 41,762 | 96–45 | |
| 143 | September 9 | | Indians | 8–7 | Arroyo (14–3) | Funk (11–10) | | | 37,161 | 97–45 | |
| 144 | September 10 | | Indians | 7–6 | Coates (11–5) | Locke (4–4) | Arroyo (27) | | | 98–45 | |
| 145 | September 10 | | Indians | 9–3 | Daley (11–16) | Perry (10–14) | | | 57,824 | 99–45 | |
| 146 | September 12 | | @ White Sox | 4 – 3 (6) | Terry (14–2) | Pierce (9–9) | | | 36,166 | 100–45 | |
| 147 | September 14 | | @ White Sox | 8–3 | Herbert (10–12) | Sheldon (9–5) | Hacker (7) | | | 100–46 | |
| 148 | September 14 | | @ White Sox | 4–3 | Kemmerer (3–3) | Arroyo (14–4) | | | 18,120 | 100–47 | |
| 149 (1) | | 6:00 p.m. EST | @ Tigers | W 11–1 | Ford (24–3) | Mossi (14–7) | — | 2:47 | — | 101–47 | W1 |
| 150 (2) | | 9:12 p.m. EST | @ Tigers | L 2–4 | Kline (7–8) | Daley (11–17) | — | 2:32 | 42,267 | 101–48 | L1 |
| 151 | | 1:30 p.m. EST | @ Tigers | L 4–10 | Lary (21–9) | Terry (14–3) | — | 2:32 | 35,820 | 101–49 | L2 |
| 152 | | 1:30 p.m. EST | @ Tigers | W 6–4 (12) | Arroyo (15–4) | Fox (4–2) | — | 3:46 | 44,219 | 102–49 | W1 |
| 153 (1) | | 6:00 p.m. EST | @ Orioles | L 0–1 | Barber (17–11) | Ford (24–4) | — | 2:27 | — | 102–50 | L1 |
| 154 (2) | | 8:52 p.m. EST | @ Orioles | W 3–1 | Daley (12–17) | Brown (10–6) | — | 2:08 | 31,317 | 103–50 | W1 |
| 155 | | 8:00 p.m. EST | @ Orioles | W 4–2 | Terry (15–3) | Pappas (12–9) | — | 2:00 | 21,032 | 104–50 | W2 |
| 156 | | 8:00 p.m. EST | @ Orioles | L 3–5 | Fisher (10–12) | Stafford (13–8) | — | 2:04 | 22,089 | 104–51 | L1 |
| 157 | September 23 | | @ Red Sox | 8–3 | Ford (25–4) | Schwall (15–6) | Arroyo (28) | | 28,128 | 105–51 | |
| 158 | September 24 | | @ Red Sox | 3–1 | Monbouquette (14–13) | Arroyo (15–5) | | | 30,802 | 105–52 | |
| 159 | | 8:00 p.m. EST | Orioles | W 3–2 | Sheldon (10–5) | Fisher (10–13) | — | 2:13 | 19,401 | 106–52 | W1 |
| 160 | | 2:00 p.m. EST | Orioles | L 2–3 | Barber (18–12) | Stafford (13–9) | Hall (4) | 2:07 | 7,594 | 106–53 | L1 |
| 161 | September 29 | | Red Sox | 2–1 | Sheldon (11–5) | Monbouquette (14–14) | | | 21,485 | 107–53 | |
| 162 | September 30 | | Red Sox | 3–1 | Terry (16–3) | Schwall (15–7) | Coates (5) | | 19,061 | 108–53 | |
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October: 1–0 (Home: 1–0; Away: 0–0)
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