1,4-Benzodioxine

1,4-Benzodioxine
Skeletal formula
Ball-and-stick model
Names
Preferred IUPAC name
1,4-Benzodioxine
Other names
Benzo[b][1,4]dioxine
Identifiers
3D model (JSmol)
ChemSpider
UNII
  • InChI=1S/C8H6O2/c1-2-4-8-7(3-1)9-5-6-10-8/h1-6H checkY
    Key: HPARLNRMYDSBNO-UHFFFAOYSA-N checkY
  • InChI=1/C8H6O2/c1-2-4-8-7(3-1)9-5-6-10-8/h1-6H
    Key: HPARLNRMYDSBNO-UHFFFAOYAC
  • O1C=COc2ccccc12
  • O1C=COC2=CC=CC=C12
Properties
C8H6O2
Molar mass 134.134 g·mol−1
Density 1.201 g cm−3
Boiling point 193 °C; 379 °F; 466 K
log P 1.6
Vapor pressure 183 Pa
Hazards
Flash point 63 °C (145 °F; 336 K)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

1,4-Benzodioxine, in chemistry, especially organic chemistry, is an aromatic ring. It is used as a versatile template for drug design.[1][2]

See also

References

  1. ↑ Bolchi, Cristiano; Bavo, Francesco; Appiani, Rebecca; Roda, Gabriella; Pallavicini, Marco. "1,4-Benzodioxane, an evergreen, versatile scaffold in medicinal chemistry: A review of its recent applications in drug design". European Journal of Medicinal Chemistry. 200 112419. doi:10.1016/j.ejmech.2020.112419. hdl:2434/742268.
  2. ↑ Harrak, Y.; Rosell, G.; Daidone, G.; Plescia, S.; Schillaci, D.; Pujol, M. D. (2007-07-15). "Synthesis and biological activity of new anti-inflammatory compounds containing the 1,4-benzodioxine and/or pyrrole system". Bioorganic & Medicinal Chemistry. 15 (14): 4876–4890. doi:10.1016/j.bmc.2007.04.050. ISSN 0968-0896.
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